Abstract: The Research Center on Flood & Drought Disaster Reduction of the Ministry of Water Resource, established in 2001, has been committed to the research of flood prevention and drought relief for a long time and becomes an important scientific research force in flood prevention and disaster reduction in China. This paper summarizes the academic achievements of the research center in the national strategy of the flood prevention and disaster reduction, flood mechanism, flood forecasting, flood regulation, flood loss assessment, flood prevention and decision support, engineering technology, which effectively supports the development of flood prevention and disaster reduction business.