Abstract: At present, the designed dispatching operation mode of reservoirs in the upper reaches of Wanquan River Basin during flood season has limited effect on the flood prevention of the lower reaches. The water security of Boao Lecheng International Medical Tourism Pilot-zone has some problems, and there are still shortcomings. In order to give full play to the role of upstream reservoirs group in regulating, storing and reducing floods, tap the potential of flood regulation, more effectively control floods in mountain areas, and ensure water safety in downstream flood protection areas, combined with typhoon forecast, study the methods of graded discharge and control, additional discrimination conditions, preemptive discharge, dynamic control of flood limit water level, etc., this paper establish joint- regulation model of river channel (embankment) and multi-reservoir (sluice) group, analyze the composition of different typical design floods and propose a safe, effective, economical and reasonable optimal dispatching scheme of flood prevention of multi-reservoir group, which is of great significance to the layout of flood management system, the reduction of project construction investment, and the guidance of actual operation.