Abstract: This paper introduces the practice of Shenzhen in the release system of meteorological disaster warning signals and the linkage response mechanism led by meteorological disaster warning signals since 1993. In the past 30 years, Shenzhen has established early warning signals of meteorological disasters such as typhoon and rainstorm, and an automatic response mechanism for typhoon and flood prevention of urban headquarters. The early warning signals of meteorological disasters have become the message tree and the starting gun for Shenzhen governments at all levels, enterprises and the public to defend against meteorological disasters, playing an important role in preventing and reducing disaster losses, protecting people's lives and property safety and so on. Through reviewing the exploration and practice of the early warning signal and linkage response mechanism of meteorological disasters in Shenzhen, it is expected to provide reference for the prevention of meteorological disasters throughout the country.