Abstract: The evaluation of the susceptibility of slope geological hazards in the Yangtze River basin will provide support for the prevention and control of slope geological hazards and the construction of water projects in the Yangtze River basin. Based on the hazard generating environment, triggering factors and dynamic characteristics of slope geological disasters, 10 factors including elevations, slopes, aspects, lithology, fault distances, river system distances, distances to epicenter, annual average precipitation, distances to roads and surface deformations are selected as evaluation factors. Combined with historical slope geological hazards points in the Yangtze River basin, random forest model is used to evaluate the susceptibility of slope geological hazards in the Yangtze River basin, which is divided into extremely low, low, medium, high and extremely high levels. The accuracy of the assessment model for the susceptibility of slope geological hazards in the Yangtze River basin is 0.95. The assessment results show that the area of extremely high prone areas accounts for 4% of the total area, and the number of historical slope geological hazards in extremely high prone areas accounts for 41% of the total numbers. The three factors of elevation, slope and annual average precipitation have made great contributions to the occurrence of slope geological hazards. Four high risk areas of slope geological hazards are divided in the Yangtze River basin. The evaluation results of the susceptibility of slope geological hazards in the Yangtze River basin are highly accurate, and the high-risk areas of slope geological hazards are reasonably divided.